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Carotid petrous segment aneurysm presenting as hypoglossal nerve palsy
Carotid petrous segment aneurysm presenting as hypoglossal nerve palsy: AbstractAneurysm in the petrous segment of the internal carotid artery is extremely rare, and symptoms are usually derived from compression of neighbor structures such as nerve palsies. Clinical symptoms can be nonspecific and imaging findings are complex, making the diagnosis of this kind of aneurysms extremely challenging. CT angiography is the best diagnostic tool, and treatment options include surgical and endovascular approaches,…
Medicine by Alexandros G. Sfakianakis
10:56
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Assessment of de novo Protein Synthesis Rates in Caenorhabditis elegans.Related Articles Assessment of de novo Protein Synthesis Rates in Caenorhabditis elegans. J Vis Exp. 2020 Sep 12;(163): Authors: Papandreou ME, Palikaras K, Tavernarakis N Abstract Maintaining a healthy proteome is essential for cell and organismal homeostasis. Perturbation of the balance between protein translational control and degradation instigates a multitude of age-related diseases. Decline of proteostasis quality control…
Medicine by Alexandros G. Sfakianakis
10:54
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Adult pancreatic hemangioma: a rare case report and literature review.Related Articles Adult pancreatic hemangioma: a rare case report and literature review. BMC Surg. 2020 Jun 03;20(1):118 Authors: Jin C, Mo JG, Jiang H, Wang LZ, Zou H, Wang KP Abstract BACKGROUND: Adult pancreatic hemangioma is an extremely rare type of benign vascular tumor. To date, about 20 cases have been reported in the English literature. Adult patients with pancreatic hemangiomas usually have no specific symptoms, particularly…
Medicine by Alexandros G. Sfakianakis
10:52
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
A Review of the Effects of Abacus Training on Cognitive Functions and Neural Systems in Humans.Related Articles A Review of the Effects of Abacus Training on Cognitive Functions and Neural Systems in Humans. Front Neurosci. 2020;14:913 Authors: Wang C Abstract Abacus, which represents numbers via a visuospatial format, is a traditional device to facilitate arithmetic operations. Skilled abacus users, who have acquired the ability of abacus-based mental calculation (AMC), can perform fast and accurate…
Medicine by Alexandros G. Sfakianakis
10:49
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
An Invited Commentary on "One-stitch versus Traditional Method of Protective Loop Ileostomy in Laparoscopic Low Anterior Rectal Resection: A Retrospective comparative Study" (International Journal of Surgery 2020; 80:117-123).Related Articles An Invited Commentary on "One-stitch versus Traditional Method of Protective Loop Ileostomy in Laparoscopic Low Anterior Rectal Resection: A Retrospective comparative Study" (International Journal of Surgery 2020; 80:117-123). Int J Surg. 2020 Sep 24;: Authors:…
Medicine by Alexandros G. Sfakianakis
10:47
Patients with Early-Onset Rectal Cancer Aged 40 Year or Less Have Similar Oncologic Outcomes to Older Patients Despite Presenting in More Advanced Stage; A Retrospective Cohort Study.
Patients with Early-Onset Rectal Cancer Aged 40 Year or Less Have Similar Oncologic Outcomes to Older Patients Despite Presenting in More Advanced Stage; A Retrospective Cohort Study.: Related ArticlesPatients with Early-Onset Rectal Cancer Aged 40 Year or Less Have Similar Oncologic Outcomes to Older Patients Despite Presenting in More Advanced Stage; A Retrospective Cohort Study.Int J Surg. 2020 Sep 24;:Authors: Emile SH, Elfeki H, Shalaby M, Elbalka S, Metwally IH, Abdelkhalek MAbstract …
Medicine by Alexandros G. Sfakianakis
10:42
Tumour-associated tissue eosinophilia (TATE) in oral squamous cell carcinoma
Tumour-associated tissue eosinophilia (TATE) in oral squamous cell carcinoma: a comprehensive review.: Related ArticlesTumour-associated tissue eosinophilia (TATE) in oral squamous cell carcinoma: a comprehensive review.Histol Histopathol. 2020 Sep 28;:18250Authors: Mascitti M, Togni L, Rubini C, Troiano G, Lo Muzio L, Santarelli AAbstract Oral squamous cell carcinoma is the most common head and neck malignancy, characterised by high invasive capacity, lymph node metastasis, and high recurrence…
Medicine by Alexandros G. Sfakianakis
10:42
Application of platelet-rich plasma (PRP) improves self-renewal of human spermatogonial stem cells in two-dimensional and three-dimensional culture systems
Application of platelet-rich plasma (PRP) improves self-renewal of human spermatogonial stem cells in two-dimensional and three-dimensional culture systems: Publication date: December 2020Source: Acta Histochemica, Volume 122, Issue 8Author(s): Farnaz Khadivi, Morteza Koruji, Mohammad Akbari, Ayob Jabari, Ali Talebi, Sepideh Ashouri Movassagh, Amin Panahi Boroujeni, Narjes Feizollahi, Aghbibi Nikmahzar, Mohammad Pourahmadi, Mehdi AbbasiAbstractSpermatogonial stem cells (SSCs) are very sensitive to…
Medicine by Alexandros G. Sfakianakis
10:41
Tumor-associated macrophages derived from cancer stem cells
Tumor-associated macrophages derived from cancer stem cells: Publication date: December 2020Source: Acta Histochemica, Volume 122, Issue 8Author(s): Amira Osman, Miharu Oze, Said M. Afify, Ghmkin Hassan, Samah EL-Ghlban, Hend M. Nawara, Xiaoying Fu, Maram Hussein Zahra, Akimasa Seno, Ira Winer, David S. Salomon, Masaharu SenoAbstractMacrophages are the most abundant immune cells in the microenvironment of solid tumors. The present study displayed histological and immunohistochemical analyses of a…
Medicine by Alexandros G. Sfakianakis
10:41
Immunotherapy for primary and secondary brain tumors
The current state of immunotherapy for primary and secondary brain tumors: similarities and differences.: Related ArticlesThe current state of immunotherapy for primary and secondary brain tumors: similarities and differences.Jpn J Clin Oncol. 2020 Sep 28;:Authors: Nejo T, Mende A, Okada HAbstract Treatment and resolution of primary and metastatic brain tumors have long presented a challenge to oncologists. In response to the dismal survival outcomes associated with conventional therapies,…
Medicine by Alexandros G. Sfakianakis
10:40
Current research progress in allergic conjunctival diseases
Current research progress in allergic conjunctival diseases: Publication date: October 2020Source: Allergology International, Volume 69, Issue 4Author(s): Atsuki FukushimaIn Allergology International (AI), Vol. 69, Issue 4, we feature a set of review articles entitled “Current research progress in allergic conjunctival diseases”. We believe that this issue will greatly contribute to our readers’ understanding of the epidemiology and future directions of diagnostic and therapeutic approaches for allergic…
Medicine by Alexandros G. Sfakianakis
10:39
The Effects of Respiratory Training in Parkinson’s Disease
The Effects of Respiratory Training in Parkinson’s Disease: A Systematic Review.: The Effects of Respiratory Training in Parkinson’s Disease: A Systematic Review.J Parkinsons Dis. 2020 Sep 21;:Authors: van de Wetering-van Dongen VA, Kalf JG, van der Wees PJ, Bloem BR, Nijkrake MJAbstract BACKGROUND: Signs of respiratory dysfunction can be present already early in the course of Parkinson’s disease (PD). Respiratory training could alleviate this, but its effectiveness is not well understood….
Medicine by Alexandros G. Sfakianakis
10:39
Platelets in Sepsis:
Platelets in Sepsis: An Update on Experimental Models and Clinical Data.: Related ArticlesPlatelets in Sepsis: An Update on Experimental Models and Clinical Data.Front Immunol. 2019;10:1687Authors: Assinger A, Schrottmaier WC, Salzmann M, Rayes JAbstract Beyond their important role in hemostasis, platelets play a crucial role in inflammatory diseases. This becomes apparent during sepsis, where platelet count and activation correlate with disease outcome and survival. Sepsis is caused by…
Medicine by Alexandros G. Sfakianakis
10:38
Liquid biopsy for ALK-positive early non-small-cell lung cancer predicts disease relapse
Liquid biopsy for ALK-positive early non-small-cell lung cancer predicts disease relapse: Future Oncology, Ahead of Print. Background: We aimed to determine whether circulating tumor cells (CTCs) and cell-free DNA (cfDNA) aids in prognosis of relapse-free survival (RFS). Methods: Non-small cell lung cancer patients with ALK mutations were recruited prospectively. CTCs and cfDNA were quantified at different time points. RFS was estimated and correlated. Results: Baseline median CTCs and cfDNA were…
Medicine by Alexandros G. Sfakianakis
10:38
Epigenomic profiling of primate Lymphoblastoid cell lines (LCLs)
Epigenomic profiling of primate LCLs reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures [NEW RESULTS]: To gain insight into the evolution of the epigenetic regulation of gene expression in primates, we extensively profiled a new panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone marks, ATAC-seq and RNA-seq, further complemented with WGS and WGBS. We annotated regulatory elements and…
Medicine by Alexandros G. Sfakianakis
10:37
Treadmill exercise ameliorates memory deficits and hippocampal inflammation
Treadmill exercise ameliorates memory deficits and hippocampal inflammation in ovalbumin-sensitized juvenile rats: Publication date: Available online 28 September 2020Source: Brain Research BulletinAuthor(s): Amin Mokhtari-Zaer, Mahmoud Hosseini, Nama Mohammadian Roshan, Mohammad Hossein BoskabadyHighlights•OVA-sensitization induced cognitive deficits.•OVA-sensitization increased blood total and differential WBC and hippocampus TNF-α.•Exercise ameliorated these changes and increased the IL-10 level…
Medicine by Alexandros G. Sfakianakis
10:36
Bulbocodin D as a potential multi-target agent for Alzheimer’s disease
Biological evaluation of naturally occurring Bulbocodin D as a potential multi-target agent for Alzheimer’s disease: Publication date: Available online 28 September 2020Source: Brain Research BulletinAuthor(s): Fengjin Hao, Yueqin FengHighlights•Bulbocodin D can reverse the apoptosis of SY5Y cells induced by H2O2.•Bulbocodin D can inhibit the cytokines of BV2 cells induced by LPS.•Bulbocodin D had a good inhibitory effect on AChE and GSK3β in silico.AbstractIn recent years, with the in-depth understanding…
Medicine by Alexandros G. Sfakianakis
10:35
Chediak Higashi disease ….present in early childhood with partial oculocutaneous albinism, a bleeding diathesis, recurrent infections secondary to immune dysfunction, and risk of developing hemophagocytic lymphohistiocytosis (HLH)
Diagnosis of Chediak Higashi disease in a 67‐year old woman: AbstractChediak‐Higashi disease is a rare disease caused by bi‐allelic mutations in the lysosomal trafficking regulator gene, LYST. Individuals typically present in early childhood with partial oculocutaneous albinism, a bleeding diathesis, recurrent infections secondary to immune dysfunction, and risk of developing hemophagocytic lymphohistiocytosis (HLH). Without intervention, mortality is high in the first decade of life. However, some…
Medicine by Alexandros G. Sfakianakis
10:34
Effectiveness of myringoplasty in patients with eosinophilic otitis media
Effectiveness of myringoplasty in patients with eosinophilic otitis media: Publication date: Available online 29 September 2020Source: Auris Nasus LarynxAuthor(s): Yoshihiko Esu, Satoru Tamii, Maria Masuda, Yukiko Iino, Naohiro YoshidaAbstractObjectiveTo determine whether myringoplasty can be an effective tool to control eosinophilic otitis media and improve hearing.MethodsSeverity scores for patients with eosinophilic otitis media with or without myringoplasty were retrospectively analyzed. Surgical…
Medicine by Alexandros G. Sfakianakis
10:33
Effectiveness of intraoperative facial nerve monitoring and risk factors related to postoperative facial nerve paralysis in patients with benign parotid tumors: A 20-year study with 902 patients
Effectiveness of intraoperative facial nerve monitoring and risk factors related to postoperative facial nerve paralysis in patients with benign parotid tumors: A 20-year study with 902 patients: Publication date: Available online 29 September 2020Source: Auris Nasus LarynxAuthor(s): Ichita Kinoshita, Ryo Kawata, Masaaki Higashino, Shuji Nishikawa, Tetsuya Terada, Shin-Ichi HaginomoriAbstractObjectiveWe examined the incidence, risk factors, and recovery time for postoperative facial nerve paralysis…
Medicine by Alexandros G. Sfakianakis
10:32
Necroptotic neuronal cell death in amyotrophic lateral sclerosis: A relevant hypothesis with potential therapeutic implication?
Necroptotic neuronal cell death in amyotrophic lateral sclerosis: A relevant hypothesis with potential therapeutic implication?: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Mathilde Chevin, Guillaume Sébire, Paul Deltenre, Hazim KadhimAbstractNecroptosis is emerging among possible mechanisms underlying cell death in neurodegenerative diseases. In this line, we hypothesize that necroptosis might be implicated in neuronal cell death in amyotrophic lateral sclerosis…
Medicine by Alexandros G. Sfakianakis
10:32
Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesis
Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesis: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): George D. VavougiosAbstractThere is a growing body of evidence on the significance of interactions between comorbidities, their treatments and COVID-19 clinical phenotypes. The hypothesis explored herein is that pharmaceutical compounds currently in use are affecting COVID-19 susceptibility and phenotypes by overlapping…
Medicine by Alexandros G. Sfakianakis
10:31
Advanced drug delivery systems can assist in managing influenza virus infection: A hypothesis
Advanced drug delivery systems can assist in managing influenza virus infection: A hypothesis: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yinghan Chan, Sin Wi Ng, Meenu Mehta, Krishnan Anand, Sachin Kumar Singh, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal DuaAbstractOutbreaks of influenza infections in the past have severely impacted global health and socioeconomic growth. Antivirals and vaccines are remarkable medical innovations that have been successful in…
Medicine by Alexandros G. Sfakianakis
10:31
Can palatovaginal canal be the site of origin of juvenile nasopharyngeal angiofibroma?
Can palatovaginal canal be the site of origin of juvenile nasopharyngeal angiofibroma?: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): A.K. Kairo, R. Kumar, S.C. SharmaJuvenile nasopharyngeal angiofibroma (JNA) is the most common benign tumor of the nasopharynx. For reasons unknown, this tumor is found almost always in male population. However, site of origin of JNA is still an enigma. Previously, JNA was considered to arise from the superior aspect of sphenopalatine…
Medicine by Alexandros G. Sfakianakis
10:30
Smart polymeric eye gear: A possible preventive measure against ocular transmission of COVID-19
Smart polymeric eye gear: A possible preventive measure against ocular transmission of COVID-19: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Dipak Kumar Sahu, Deepak Pradhan, Pradeep Kumar Naik, Biswakanth Kar, Goutam Ghosh, Goutam RathAbstractThe angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic…
Medicine by Alexandros G. Sfakianakis
10:29
Role of testosterone in COVID-19 patients
Role of testosterone in COVID-19 patients – A double-edged sword?: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Aneela N. Hussain, Fazal Hussain, Shahrukh K. HashmiAbstractCOVID-19 affects males twice as frequently as females with significantly increased severity and mortality. Current data suggest a direct correlation between the lower level of serum testosterone, inflammatory cytokines, disease severity, and poor clinical outcomes among male patients with COVID-19….
Medicine by Alexandros G. Sfakianakis
10:28
Potential role of GcMAF in suppressing the severity of COVID-19-induced immune responses: Lesson learned from HIV
Potential role of GcMAF in suppressing the severity of COVID-19-induced immune responses: Lesson learned from HIV: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Lucrezia Spadera, Maria SpaderaIntroductionOver the last six months, there have been increasing numbers of reports that struggle to understand the pathogenesis of the coronavirus disease 2019 (COVID-19) pandemic.As of August 16, 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been…
Medicine by Alexandros G. Sfakianakis
10:27
Factors related to asymptomatic or severe COVID-19 infection
Factors related to asymptomatic or severe COVID-19 infection: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Author links open overlay panelEduardo Pérez-CamposMayoralaeMaría TeresaHernández-HuertabeLauraPérez-Campos Mayoralae1Carlos AlbertoMatias-CervantesbeGabrielMayoral-AndradeaeLuis Ángel LagunaBarriosceEduardoPérez-Camposcde1aCentro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca,…
Medicine by Alexandros G. Sfakianakis
10:26
Role of inositol to improve surfactant functions and reduce IL-6 levels: A potential adjuvant strategy for SARS-CoV-2 pneumonia?
Role of inositol to improve surfactant functions and reduce IL-6 levels: A potential adjuvant strategy for SARS-CoV-2 pneumonia?: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Antonio Simone Laganà, Vittorio Unfer, Simone Garzon, Mariano BizzarriAbstractTo date, the spread of SARS-CoV-2 infection is increasing worldwide and represents a primary healthcare emergency. Although the infection can be asymptomatic, several cases develop severe pneumonia and acute respiratory…
Medicine by Alexandros G. Sfakianakis
10:25
The COVID-19 Score can predict the need for tracheal intubation in critically ill COVID-19 patients – A hypothesis
The “COVID-19 Score” can predict the need for tracheal intubation in critically ill COVID-19 patients – A hypothesis: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Ankur Khandelwal, Gyaninder Pal Singh, Girija Prasad Rath, Arvind ChaturvediEditor,With the ongoing COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the global health care has suffered major disruptions. In particular, the health care workers (HCWs) across the world…
Medicine by Alexandros G. Sfakianakis
10:25
Nerve regeneration and ischemia based on the sciatic nerve and femoral artery
A Yorkshire swine (<em>Sus scrofa domesticus</em>) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery: Publication date: Available online 28 September 2020Source: Annals of Anatomy – Anatomischer AnzeigerAuthor(s): Sarah E. Kinsley, Stephen D. Fernicola, Marvin E. Dingle, Milfred S. Williams, Jody M. Richardson, Dennis Taylor, Jaira F. de Vasconcellos, Timothy R. Malone, Matthew R. Blattner, Jonathan K. Smith, Alli Oliver, Amory L. Koch, Laura E. Riddle,…
Medicine by Alexandros G. Sfakianakis
10:19
Intranasal Tofacitinib on Chronic Rhinosinusitis with Nasal Polyps…Η τοφασιτινίμπη (tofacitinib) είναι ένας ισχυρός, εκλεκτικός αναστολέας της οικογένειας JAK. Σε ανθρώπινα κύτταρα, η τοφασιτινίμπη αναστέλλει, κατά προτίμηση, τη σηματοδότηση από ετεροδιμερείς υποδοχείς κυτοκινών που συσχετίζονται με την JAK3 ή/και την JAK1. Η αναστολή των JAK1 και JAK3 από την τοφασιτινίμπη εξασθενεί τη σηματοδότηση των ιντερλευκινών και των ιντερφερονών τύπου I και τύπου II, γεγονός που προκαλεί τροποποίηση της ανοσολογικής και φλεγμονώδους απόκρισης.
Therapeutic Effects of Intranasal Tofacitinib on Chronic Rhinosinusitis with Nasal Polyps in Mice: ObjectivesThe Janus kinase/signal transducer and activator of transcription (JAK–STAT) pathway play a key role in immune modulation, especially in the polarization of T helper cells. JAK inhibitors reduce inflammation by inhibiting the phosphorylation of STAT. We investigated whether a JAK inhibitor, tofacitinib, can reduce inflammation in a mouse model of chronic rhinosinusitis with nasal polyps (CRSwNP).MethodsAn…
Medicine by Alexandros G. Sfakianakis
10:17
Incidence of metastasis to level V lymph nodes in clinically positive necks among Sri Lankan patients with oral squamous cell carcinoma
Incidence of metastasis to level V lymph nodes in clinically positive necks among Sri Lankan patients with oral squamous cell carcinoma: Publication date: Available online 28 September 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Nadeena Sri Swarnaguptha Jayasuriya, Navini Thathsara Mannapperuma, Samadarani Siriwardana, Ajith Manjula Attygalla, Sandali DeSilva, Hareendra Jinadasa, Rasika Ekanayaka, Dayanath K. Dias, Saminda Wadusinghearachi, Irosha PereraAuthor links open…
Medicine by Alexandros G. Sfakianakis
10:15
Tendon function after replantation of complete thumb avulsion amputations
Tendon function after replantation of complete thumb avulsion amputations: Tendon avulsion at the musculotendinous junction caused by digit avulsion amputation is still a challenging problem. We compared two tendon repair methods in patients with complete thumb avulsion amputations (reattachment to muscle versus tendon transfer). Our retrospective study found that tendon transfer can attain higher pinch strength for replantation of thumb avulsion amputations. It is recommended for patients with…
Medicine by Alexandros G. Sfakianakis
10:14
Cholesteatoma Classification
Cholesteatoma Classification: Review of Literature and Proposed Indian Classification System—TAMPFIC: AbstractClassification systems provides a tool for segregating cases based on their similarities. It can be used by healthcare professionals for representation, comparison, communication, discussion and for standardizing treatment protocols across the geographical boundaries. Cholesteatoma is prevalent in developed as well as developing nations posing a great burden on economic and health sector….
Medicine by Alexandros G. Sfakianakis
10:13
Narcolepsy type 2
Narcolepsy type 2: A rare, yet existing entity: AbstractBecause of unspecific diagnostic criteria, there is much controversy around narcolepsy type 2, its existence and its frequency. With this retrospective and purely descriptive study, we aimed to compare the frequency of narcolepsy type 2 compared to the well‐described narcolepsy type 1, in a large (n = 3,782) retrospective sample from a single tertiary sleep centre. After 2 weeks washout of sleep–wake active medication, all patients with excessive…
Medicine by Alexandros G. Sfakianakis
10:13
Cold atmospheric plasma on bacterial contamination and healing tendency of chronic wounds
Pilot study on the influence of cold atmospheric plasma on bacterial contamination and healing tendency of chronic wounds: SummaryBackgroundCold atmospheric plasma (CAP) has been used successfully for wound treatment, with thrice weekly treatment intervals. In this study, we wished to investigate whether comparably beneficial results can be achieved even with once weekly CAP treatment.Patients and methodsIn this randomized clinical pilot study (RCT) patients with therapy‐refractory chronic wounds…
Medicine by Alexandros G. Sfakianakis
10:12
Clear cell acanthoma……………a red papule a few millimeters in diameter that often occurs as a single lesion on the lower extremities
Clear cell acanthoma: SummaryClear cell acanthoma is a rarely diagnosed tumor with variable clinical morphology that is usually only recognized by its histopathological features. The primary lesion is a red papule a few millimeters in diameter that often occurs as a single lesion on the lower extremities. In dermoscopy, resemblance of the vessels to a string of pearls is a largely specific finding of clear cell acanthoma. In contrast to the initially uncharacteristic clinical findings, histopathology…
Medicine by Alexandros G. Sfakianakis
10:11
Transposition flap plastic to cover an extensive defect of the upper lip region after resection of a microcystic adnexal carcinoma
Transposition flap plastic to cover an extensive defect of the upper lip region after resection of a microcystic adnexal carcinoma:
Medicine by Alexandros G. Sfakianakis
10:11
Αφαίρεση διαφημίσεων
Eyelid reconstruction with modified Tenzel flap after lentigo maligna melanoma resection
Eyelid reconstruction with modified Tenzel flap after lentigo maligna melanoma resection:
Medicine by Alexandros G. Sfakianakis
10:10
Subantimicrobial dose doxycycline in rosacea
Evaluation of the efficacy of subantimicrobial dose doxycycline in rosacea: a systematic review of clinical trials and meta‐analysis: SummaryBackgroundLow‐dose doxycycline (SDD) is an antimicrobial agent that appears to improve common inflammatory skin diseases. Few data are available regarding the overall effectiveness, appropriate length of treatment and optimal patient selection for rosacea. We therefore reviewed the efficacy of sub‐antimicrobial doses of SDD in papulopustular rosacea (PPR) and…
Medicine by Alexandros G. Sfakianakis
10:09
Hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs (NSAIDs) – a retrospective study
Hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs (NSAIDs) – a retrospective study: SummaryBackgroundThe aim of this study was to verify the validity of clinical history and oral provocation challenges of patients with NSAID hypersensitivity and to identify safe alternatives. The COX‐2 inhibitor etoricoxib, in particular, was studied.Patients and methodsIn all, 104 patients with confirmed diagnoses of NSAID hypersensitivity treated at the Department of Dermatology, Frankfurt University…
Medicine by Alexandros G. Sfakianakis
10:09
Severe skin fragility with postnatal lethal outcome due to a biallelicKRT5 mutation
Severe skin fragility with postnatal lethal outcome due to a biallelicKRT5 mutation:
Medicine by Alexandros G. Sfakianakis
10:09
Rapid recurrence in head and neck cancer
Rapid recurrence in head and neck cancer: Underappreciated problem with poor outcome: AbstractBackgroundRapid recurrence, defined as gross tumor recurrence after primary operation but prior to initiating postoperative radiation therapy (PORT), is underappreciated in head and neck cancer (HNC).MethodsCT simulation images in patients with HNC managed surgically with adjuvant therapy at a single center between 2010 and 2017 were retrospectively reviewed.ResultsA total of 194 patients with HNC were included….
Medicine by Alexandros G. Sfakianakis
10:08
Tooth ultrastructure of a novel COL1A2 mutation expanding its genotypic and phenotypic spectra
Tooth ultrastructure of a novel COL1A2 mutation expanding its genotypic and phenotypic spectra: AbstractObjectivesTo investigate tooth ultrastructure and mutation of two patients in a family affected with osteogenesis imperfecta (OI) type IV and dentinogenesis imperfecta (DGI).MethodsMutations were detected by whole exome and Sanger sequencing. The permanent second molar obtained from the proband (DGI1) and the primary first molar from his affected son (DGI2) were studied for their colour, roughness,…
Medicine by Alexandros G. Sfakianakis
10:08
SNHG3/miR‐2682‐5p/HOXB8 promotes cell proliferation and migration in oral squamous cell carcinoma
SNHG3/miR‐2682‐5p/HOXB8 promotes cell proliferation and migration in oral squamous cell carcinoma: AbstractObjectiveThe potential molecular mechanism underlying the disease progression of oral squamous cell carcinoma (OSCC) remains largely elusive. The purpose of the study is to figure out the role and molecular mechanism of homeobox B8 (HOXB8) in OSCC.Materials and methodsThe expression level of HOXB8 in OSCC was validated by RT‐qPCR. The functions of HOXB8 in OSCC cells were identified through…
Medicine by Alexandros G. Sfakianakis
10:07
DNA methylation alterations and their potential influence on macrophage in periodontitis
DNA methylation alterations and their potential influence on macrophage in periodontitis: AbstractObjectivesTo explore how various methylation mechanisms function and affect macrophages in periodontitis, with an aim of getting a comprehensive understanding of pathogenesis of the disease.SubjectAlterations in DNA methylation are associated with different periodontitis susceptible factors and disrupt immunity homeostasis. The host’s immune response to stimulus plays a vital role in the progression…
Medicine by Alexandros G. Sfakianakis
10:07
Low-level laser therapy (LLLT) and piezocision on the amount of orthodontic tooth movement
Which method is more effective for accelerating canine distalization short term, low-level laser therapy or piezocision? A split-mouth study: AbstractObjectivesThis study evaluated and compared the effects of low-level laser therapy (LLLT) and piezocision on the amount of orthodontic tooth movement. Materials and methodsForty maxillary canines from 20 patients (mean age, 16.35 ± 1.14 years) were evaluated in a split-mouth design study. Miniscrew-supported canine distalization…
Medicine by Alexandros G. Sfakianakis
10:07
Oxaliplatin-Induced Thrombotic Microangiopathy
Oxaliplatin-Induced Thrombotic Microangiopathy in a Patient with Stage IV Gallbladder Carcinoma: Primary Association or Multiple Hits?: Thrombotic microangiopathies (TMA) include a variety of vascular disorders characterized by the presence of microthrombi, coagulopathy by platelet activation and consumption, and systemic damage. The most frequent secondary causes are infections and some medications. However, the presence of chemotherapeutic agents is not so common, and the induction of TMA by oxaliplatin…
Medicine by Alexandros G. Sfakianakis
10:06
Frameless Stereotactic Brain Biopsy
Comparing Fiducial-Based and Intraoperative Computed Tomography-Based Registration for Frameless Stereotactic Brain Biopsy: Objective: The aim of this work was to compare fiducial-based and intraoperative computed tomography (iCT)-based registration for frameless stereotactic brain biopsy. Methods: Of 50 frameless stereotactic biopsies with the VarioGuide, 30 cases were registered as iCT based and 20 as fiducial based. Statistical analysis of the target registration error (TRE), dose length product,…
Medicine by Alexandros G. Sfakianakis
10:05
COVID‐19 and immunological dysregulation: can autoantibodies be useful?
COVID‐19 and immunological dysregulation: can autoantibodies be useful?: AbstractCoronavirus disease 2019 (COVID‐19) is often associated with interstitial pneumonia. However, there is insufficient knowledge on the presence of autoimmune serological markers in patients with COVID‐19. We analyzed the presence and role of autoantibodies in patients with COVID‐19‐associated pneumonia.We prospectively studied 33 consecutive patients with COVID‐19, 31 (94%) of whom had interstitial pneumonia, and 25 age‐…
Medicine by Alexandros G. Sfakianakis
10:05
COVID‐19 and venous thromboembolism
COVID‐19 and venous thromboembolism in intensive care or medical ward: AbstractDespite thromboprophylaxis, patients with coronavirus‐19 disease (COVID‐19) exhibit hypercoagulability and higher venous thromboembolic risk, although its real incidence is still unknown. The aim of the study was to evaluate the incidence of venous thromboembolism in COVID‐19 patients admitted to both intensive care unit and medical ward. Consecutive patients admitted for COVID‐19 to medical ward and intensive care unit…
Medicine by Alexandros G. Sfakianakis
10:04
Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis
Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis: AbstractFree radical involvement in initiation, promotion and progression of carcinogenesis, implicates that scavengers of free radicals may act as inhibitors in the carcinogenic process. Melatonin, an antioxidant was used in the present study to evaluate its effectiveness on skin carcinogenesis induced by DMBA both with and without chronic restraint stress (CRS). Fifty Swiss…
Medicine by Alexandros G. Sfakianakis
10:03
An Integrated Analysis of mRNAs and miRNAs Microarray Profiles to Screen miRNA Signatures Involved in Nasopharyngeal Carcinoma
An Integrated Analysis of mRNAs and miRNAs Microarray Profiles to Screen miRNA Signatures Involved in Nasopharyngeal Carcinoma: Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:We aim to identify several microRNAs (miRNAs/miRs)-messenger RNAs (mRNAs) biomarkers correlated to nasopharyngeal carcinoma (NPC) based on an integrated analysis of miRNA and mRNAs microarray expression profiles.Methods:The available mRNA and miRNA microarray datasets were retrieved…
Medicine by Alexandros G. Sfakianakis
09:19
Brain Metabolism and Structure in Chronic Migraine
Brain Metabolism and Structure in Chronic Migraine: AbstractPurpose of ReviewThe purpose of this paper is to review and synthesize current literature in which neurochemical and structural brain imaging were used to investigate chronic migraine (CM) pathophysiology and to further discuss the clinical implications. Recent FindingsSpectroscopic and structural MRI studies have shown the presence of both impaired metabolism and structural alterations in the brain of CM patients….
Medicine by Alexandros G. Sfakianakis
09:19
Chronic Cluster Headache
Chronic Cluster Headache Update and East–West Comparisons: Focusing on Clinical Features, Pathophysiology, and Management: AbstractPurpose of ReviewThis review provides an update on chronic cluster headache (CH) focusing on clinical features, pathophysiology, and management as well as comparisons between Eastern and Western populations. Recent FindingsChronic CH in Eastern populations was relatively rare, compared to that in Western populations. Lacrimation and/or conjunctival…
Medicine by Alexandros G. Sfakianakis
09:19
Complications Associated with Lumbar Transforaminal Epidural Steroid Injections
Complications Associated with Lumbar Transforaminal Epidural Steroid Injections: AbstractPurpose of ReviewLow back pain with radicular symptoms is a common cause of disability in the adult population in the USA. Lumbar transforaminal epidural steroid injection (TFESI) is one of the most frequently used intervention for lumbar radiculitis. The purpose of this review is to evaluate complications associated with lumbar TFESI. Recent FindingsBased on the literature review, the…
Medicine by Alexandros G. Sfakianakis
09:19
CD4+ T lymphocyte count remains the most common biomarker of immune status and disease progression in human immunodeficiency virus (HIV)-positive individuals……………………….Instrument-free point-of-care CD4 test (VISITECT®CD4)
Performance characteristics of an instrument-free point-of-care CD4 test (VISITECT®CD4) for use in resource-limited settings: Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveCD4+ T lymphocyte count remains the most common biomarker of immune status and disease progression in human immunodeficiency virus (HIV)-positive individuals. VISITECT®CD4 is an instrument-free, low-cost point-of-care CD4 test with a cut-off of 350 CD4 cells/μL. This study aimed to evaluate…
Medicine by Alexandros G. Sfakianakis
09:18
Spontaneous ovarian hyperstimulation syndrome in a nonpregnant female patient
Spontaneous ovarian hyperstimulation syndrome in a nonpregnant female patient: a case report and literature review: Journal of International Medical Research, Volume 48, Issue 9, September 2020. Spontaneous ovarian hyperstimulation syndrome (sOHSS) usually occurs in patients with a spontaneous ovulation cycle, especially in those with multiple pregnancies combined with hypothyroidism and polycystic ovary syndrome. sOHSS rarely occurs in women who are not pregnant. A 23-year-old woman with obvious…
Medicine by Alexandros G. Sfakianakis
09:17
Αφαίρεση διαφημίσεων
ST-segment elevation myocardial infarction (STEMI) :bivalirudin application during primary percutaneous coronary intervention in older patients with acute ST-segment elevation myocardial infarction
Efficacy and safety of bivalirudin application during primary percutaneous coronary intervention in older patients with acute ST-segment elevation myocardial infarction: Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveST-segment elevation myocardial infarction (STEMI) is the most serious type of acute coronary syndrome. This study aimed to investigate the efficacy and safety of bivalirudin application during primary percutaneous coronary intervention (PPCI)…
Medicine by Alexandros G. Sfakianakis
09:17
Association of spontaneous cerebrospinal fluid rhinorrhea with transverse venous sinus stenosis
Association of spontaneous cerebrospinal fluid rhinorrhea with transverse venous sinus stenosis: a retrospective matched case‐control study: What is transverse sinus stenosis?Transverse sinus stenosis is an imaging finding very highly associated with elevated intracranial pressure (ICP). Patients with the Chiari I malformation may potentially have elevated ICP due to impairment of CSF flow at the foramen magnum.Transverse Sinus Stenosis in Adult Patients With Chiari … – AJR
Medicine by Alexandros G. Sfakianakis
09:16
Environmental Risk Factors in Systemic Sclerosis
Toward Understanding of Environmental Risk Factors in Systemic Sclerosis: Journal of Cutaneous Medicine and Surgery, Ahead of Print. ImportanceSystemic sclerosis (SSc) is a severe, chronic, and incurable autoimmune fibrotic skin disease with significant extracutaneous involvement. Low concordance rate in twin studies and unequal geographic distribution of SSc argues for importance of environment in disease initiation and progression.ObjectiveIn this manuscript we provide a summary of all investigated…
Medicine by Alexandros G. Sfakianakis
09:14
Galvanic Vestibular Stimulation in the Rehabilitation of Patients with Vestibular Disorders
The Effect of Galvanic Vestibular Stimulation in the Rehabilitation of Patients with Vestibular Disorders: Introduction: The aim of the study was to increase the participants’ satisfaction with the unilateral peripheral vestibular pathology, in addition to the exercise program, with galvanic vestibular stimulation (GVS). Methods: Participants were divided into 2 groups: study group (41 subjects) and control group (32 subjects). Participants who underwent videonystagmography and sensory organization…
Medicine by Alexandros G. Sfakianakis
09:13
Osteopenic effects of high‐fat diet
Osteopenic effects of high‐fat diet‐induced obesity on mechanically induced alveolar bone remodeling: AbstractObjectivesThe aim of the study was to investigate the effect of obesity on the tissue and molecular reactions of alveolar bone in response to orthodontic force and its underlying mechanisms.MethodsSixty‐four rats were randomly divided into normal diet (ND) and high fat diet (HFD) groups for eight weeks of dietary treatment. OTM was induced using nickel‐titanium springs between the upper left…
Medicine by Alexandros G. Sfakianakis
09:13
Repurposing disulfiram to induce OSCC cell death by cristae dysfunction promoted autophagy
Repurposing disulfiram to induce OSCC cell death by cristae dysfunction promoted autophagy: AbstractObjectiveDisulfiram has been repurposed as a potential candidate to suppress various cancers. However, its antitumor effects and molecular mechanisms of oral squamous cell carcinoma remain unclear. In this study, we aimed to assess the anticancer activity and underlying mechanisms of disulfiram in the context of oral squamous cell carcinoma.Materials and methodsWe tested the cytotoxicity of disulfiram…
Medicine by Alexandros G. Sfakianakis
09:12
Vitamin D oral gel for prevention of radiation‐induced oral mucositis
Vitamin D oral gel for prevention of radiation‐induced oral mucositis: a randomized clinical trial: AbstractObjectivesThe aim of this clinical trial is to evaluate the effectiveness of topical oral vitamin D gel in prevention of radiation induced oral mucositis.Material and methodsA three‐armed randomized controlled clinical trial on forty‐five head and neck cancer patients was conducted. First group: conventional treatment. Second group: Topical oral vitamin D gel. Third group: topical oral vitamin…
Medicine by Alexandros G. Sfakianakis
09:12
Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated with Moringa oleifera Leaves and Seed Residue (MOLSr) Extracts
Nutrients, Vol. 12, Pages 2993: Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated with Moringa oleifera Leaves and Seed Residue (MOLSr) Extracts: Nutrients, Vol. 12, Pages 2993: Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated with Moringa oleifera Leaves and Seed Residue (MOLSr) ExtractsNutrients doi: 10.3390/nu12102993Authors: Wai Feng Lim Mohd Izwan Mohamad Yusof…
Medicine by Alexandros G. Sfakianakis
09:06
Eosinophil-Derived Neurotoxin, Tumor Necrosis Factor Alpha, and Calprotectin as Non-Invasive Biomarkers of Food Protein-Induced Allergic Proctocolitis in Infants
JCM, Vol. 9, Pages 3147: Eosinophil-Derived Neurotoxin, Tumor Necrosis Factor Alpha, and Calprotectin as Non-Invasive Biomarkers of Food Protein-Induced Allergic Proctocolitis in Infants: JCM, Vol. 9, Pages 3147: Eosinophil-Derived Neurotoxin, Tumor Necrosis Factor Alpha, and Calprotectin as Non-Invasive Biomarkers of Food Protein-Induced Allergic Proctocolitis in InfantsJournal of Clinical Medicine doi: 10.3390/jcm9103147Authors: Artur Rycyk Beata Cudowska Dariusz M. Lebensztejn Diagnosis…
Medicine by Alexandros G. Sfakianakis
09:02
18F-FDG PET/MR versus MR Alone in Whole-Body Primary Staging and Restaging of Patients with Rectal Cancer: What Is the Benefit of PET?
JCM, Vol. 9, Pages 3163: 18F-FDG PET/MR versus MR Alone in Whole-Body Primary Staging and Restaging of Patients with Rectal Cancer: What Is the Benefit of PET?: JCM, Vol. 9, Pages 3163: 18F-FDG PET/MR versus MR Alone in Whole-Body Primary Staging and Restaging of Patients with Rectal Cancer: What Is the Benefit of PET?Journal of Clinical Medicine doi: 10.3390/jcm9103163Authors: Li Mueller Neuhaus Bertram Schaarschmidt Demircioglu Ludwig Kirchner Rischpler Herrmann …
Medicine by Alexandros G. Sfakianakis
09:00
Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart Failure
IJMS, Vol. 21, Pages 7215: Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart Failure: IJMS, Vol. 21, Pages 7215: Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart FailureInternational Journal of Molecular Sciences doi: 10.3390/ijms21197215Authors: Kurtzwald-Josefson Zeevi-Levin Rubchevsky Bechar Erdman Schwartz Rohaker Nahum Hochhauser Ben-Avraham Itskovitz-Eldor…
Medicine by Alexandros G. Sfakianakis
08:59
The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and PANX2
IJMS, Vol. 21, Pages 7217: The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and PANX2: IJMS, Vol. 21, Pages 7217: The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and PANX2International Journal of Molecular Sciences doi: 10.3390/ijms21197217Authors: Ray Coulson Yeoh Tamara Latief Bakhashab Weaver Cardiovascular…
Medicine by Alexandros G. Sfakianakis
08:57
Use of Hyaluronic Acid (HA) in Chronic Airway Diseases
Cells, Vol. 9, Pages 2210: Use of Hyaluronic Acid (HA) in Chronic Airway Diseases: Cells, Vol. 9, Pages 2210: Use of Hyaluronic Acid (HA) in Chronic Airway DiseasesCells doi: 10.3390/cells9102210Authors: Luis Máiz Carro Miguel A. Martínez-García Hyaluronic acid (HA) is a key component of the extracellular matrix of the lungs. A unique attribute of HA is its water-retaining properties, so HA has a major role in the regulation of fluid balance in the lung interstitium. Hyaluronic acid has been…
Medicine by Alexandros G. Sfakianakis
08:53
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
ArtsArts, Vol. 9, Pages 101: The Work of Art Criticism: Collaboration, Communication, CommunityArts, Vol. 9, Pages 101: The Work of Art Criticism: Collaboration, Communication, Community Arts doi: 10.3390/arts9040101 Authors: Matthew Bowman This essay aims to reconsider the practice of art criticism. The first part aims to clear away some misconceptions that reduce art criticism to a fundamentally negative discourse that asserts a theory/practice distinction. In the second part, the essay tries…
Medicine by Alexandros G. Sfakianakis
08:52
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
AntibioticsAntibiotics, Vol. 9, Pages 653: Hospitalization for Acute Respiratory Tract Infection in a Low-Antibiotic-Prescribing Setting: Cross-Sectional Data from General PracticeAntibiotics, Vol. 9, Pages 653: Hospitalization for Acute Respiratory Tract Infection in a Low-Antibiotic-Prescribing Setting: Cross-Sectional Data from General Practice Antibiotics doi: 10.3390/antibiotics9100653 Authors: Christin Löffler Attila Altiner Annette Diener Reinhard Berner Gregor Feldmeier Christian Helbig…
Medicine by Alexandros G. Sfakianakis
08:51
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
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Medicine by Alexandros G.Sfakianakis
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182,alsfakia@gmail.com 